The Guardians will play the Twins on Wednesday, May 21st, 2025. This is Game 2 of a doubleheader. Your timezone's first pitch time is 6:10 pm CDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
| Bonus | |
|---|---|
  REVIEW |
PA *New* Customers - Bet $10, Get $150 in Bonus Bets If You Win Thru 6/2/2025 - Bonus Bets Expire in 7 Days One new customer offer/Add'l Bet Now 21+ Playable in PA only Gambling Problem? Call 1-800-GAMBLER |
 REVIEW |
New Customers - 2nd Chance Bet up to $500 - Code: SPORTS Bet Now 21+ Playable in PA only Gambling Problem? Call 1-800-GAMBLER |
Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Cleveland Guardians have a 90.33 power ranking. The power ranking for the Minnesota Twins is 95.00.
- Visiting Cleveland Guardians - The Cleveland Guardians have a 11-13 record as a visiting team, ranking them 4th Overall for visiting team wins.
- Home Minnesota Twins - The Minnesota Twins have a 15-6 record as a home team. They rank 3rd for home team wins in the Overall standings.
- Runs Scored - The Cleveland Guardians currently stand 22nd (182) Overall, with the Minnesota Twins ranking 19th (194) for runs scored.
- Runs Allowed - The Cleveland Guardians are 13th (202) Overall for runs allowed. The Minnesota Twins stand 26th (159) for runs allowed.
- Team Streaks - The Cleveland Guardians have lost their last 4 games. Meanwhile, the Minnesota Twins lost their last game.
- Team Records - The Cleveland Guardians have a 25-21 Overall record (5.5 GB American Central Division), with the Minnesota Twins possessing a 26-21 Overall standing (5.0 GB American Central Division).
Captain Shady Lines
A broken com is right at least twice a day.
Avast ye scallywags! The Cleveland Guardians face the Minnesota Twins on Wednesday...
These landlubbers be limping into battle with a pitiful 4-6 record lately...
SportsBetting3.com be the place to wager your doubloons, bet on this game... (review the odds below)
The Twins be on a rampage, plundering their way to a 9-1 record...
The Guardians best be prepared for a fierce showdown on foreign soil...
Ye best be ready to witness a battle of epic proportions on Wednesday!
Best Guardians at Twins Odds
| Underdog Cleveland Guardians |
Favorite Minnesota Twins |
|---|---|
| Over | Under |
|---|---|
| Underdog Minnesota Twins |
Favorite Cleveland Guardians |
|---|---|
Matchup Odds FAQs
The Minnesota Twins are the -118 moneyline favorite at BetRivers and the Cleveland Guardians are the +100 moneyline underdog at BetRivers.
The best over line is 7.5 -103 runs at BetRivers, which means you risk $103 to win $100 betting the over. The best under line is 7.5 -118 runs at BetRivers, and that means you risk $118 to win $100 betting the under.
The Cleveland Guardians are -1.5 +175 run line favorites at BetRivers, while the Minnesota Twins are +1.5 -225 run line underdogs at BetRivers.
MLB Odds Example
| Game |
 BetRiversBet |
|---|---|
|
Guardians
Twins
Doubleheader - Game 2 - 5/21/25 6:10pm CDT
|
-118 |
- Cleveland Guardians bettors risk $100 to win $100 at +100 odds. The implied probability for Cleveland Guardians is 50%.
- Minnesota Twins bettors risk $100 to win $84.75 at -118 odds. The implied probability for Minnesota Twins is 54.13%.
Cleveland Guardians at Minnesota Twins Prop Bets
 BetMGMBet |
|
|---|---|
|
Guardians
Twins
5/21/25 6:10pm CDT Doubleheader - Game 2 |
Pending BetMGM |
Cleveland Guardians & Minnesota Twins Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Cleveland Guardians World Series Odds| Team |
BetMGM |
BetRivers |
|---|---|---|
| Guardians | +5000 Bet |
+4500 Bet |
| Team |
BetMGM |
BetRivers |
|---|---|---|
| Twins | +3000 Bet |
+4000 Bet |
Cleveland Guardians & Minnesota Twins Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cleveland Guardians | 27 | 22 | 0.551 | +5.0 | 14-8 | 13-14 | 199 | 209 | -10 | W2 | 4-6 |
| Minnesota Twins | 27 | 22 | 0.551 | +5.0 | 16-7 | 11-15 | 201 | 169 | +32 | L1 | 8-2 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Cleveland Guardians vs Minnesota Twins MLB Game
- Open a new sports betting before game time.
Review our list of sports betting sites. Open a new before the game starts on Wednesday, May 21st, 2025 at 6:10 pm CDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
- Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Paypal.
- Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Minnesota Twins Game.
Navigate to the sportsbook's MLB page. Next, look for live or matchups. Select the Cleveland Guardians vs Minnesota Twins Game.
- Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your balance after the game.
Other May 21, 2025 MLB Games
- Cincinnati Reds vs Pittsburgh Pirates - 5/21/25 11:35am CDT
- Baltimore Orioles vs Milwaukee Brewers - 5/21/25 12:10pm CDT
- Chicago Cubs vs Miami Marlins - 5/21/25 12:10pm CDT
- Houston Astros vs Tampa Bay Rays - 5/21/25 12:10pm CDT
- Detroit Tigers vs St. Louis Cardinals - 5/21/25 12:15pm CDT
- Seattle Mariners vs Chicago White Sox - 5/21/25 1:10pm CDT
- Cleveland Guardians vs Minnesota Twins - 5/21/25 2:30pm CDT
- Kansas City Royals vs San Francisco Giants - 5/21/25 2:45pm CDT
- New York Mets vs Boston Red Sox - 5/21/25 5:45pm CDT
- Atlanta Braves vs Washington Nationals - 5/21/25 5:45pm CDT
- Texas Rangers vs New York Yankees - 5/21/25 6:05pm CDT
- San Diego Padres vs Toronto Blue Jays - 5/21/25 6:07pm CDT
- Philadelphia Phillies vs Colorado Rockies - 5/21/25 7:40pm CDT
- Los Angeles Angels vs Oakland Athletics - 5/21/25 9:05pm CDT
- Arizona Diamondbacks vs Los Angeles Dodgers - 5/21/25 9:10pm CDT